{"id":211,"date":"2014-04-25T11:26:17","date_gmt":"2014-04-25T11:26:17","guid":{"rendered":"http:\/\/plexusskada.se\/wordpress\/?page_id=211"},"modified":"2022-05-02T12:30:54","modified_gmt":"2022-05-02T12:30:54","slug":"forskning-vetenskap","status":"publish","type":"page","link":"https:\/\/plexusskada.se\/wordpress\/?page_id=211","title":{"rendered":"Forskning \/ Vetenskap"},"content":{"rendered":"

Plexusgruppens forskningsprojekt ber\u00f6r flera olika omr\u00e5den.<\/p>\n

Flera\u00a0forskningsprojekt\u00a0bedrivs\u00a0inom ramen f\u00f6r det kliniska arbetet\u00a0\u00a0och handlar bland annat om att utveckla instrument f\u00f6r att utv\u00e4rdera funktionen hos personer som drabbats av plexusskador och att utv\u00e4rdera effekten av kirurgisk behandling av olika slag, b\u00e5de betr\u00e4ffande reparation av nervskador och vad g\u00e4ller det vi kallar sekund\u00e4r kirurgi.<\/p>\n

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Barn med en f\u00f6delserelaterad plexusskada utvecklar ofta en en in\u00e5trotationskontraktur i den skadade armens axelled. Vi har i studier\u00a0under l\u00e5ng tid f\u00f6ljt de barn som vi opererat f\u00f6r detta f\u00f6r att se hur effekten av operationen st\u00e5r sig \u00f6ver tid (bra!) (12+13) samt granskat axelledens utveckling (14). Vidare har vi\u00a0 granskat v\u00e5r operationsteknik f\u00f6r in\u00e5trotationskontraktur i axelleden (15). Krister J\u00f6nsson har nyligen f\u00f6rsvarat dessa artiklar i sin avhandling samt en artikel d\u00e4r han i en experimentell djurstudie f\u00f6rs\u00f6ker finna m\u00f6jliga f\u00f6rklaringar p\u00e5 varf\u00f6r vissa barn med denna skada drabbas av co-kontraktioner (16), dvs samaktivering av muskler som verkar i olika riktningar. Resultatien i denna studie utesluter inte att det \u00e4r en central mekanism som orsakar denna samaktivering.<\/p>\n

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Vid den neurovetenskapliga institutionen vid Karolinska Institutet i Solna bedrivs grundforskning kring nervskador och nervl\u00e4kning.\u00a0\u00a0H\u00e4r p\u00e5g\u00e5r bl.a. sedan decennier experimentell forskning kring l\u00e4kning i gr\u00e4nszonen mellan ryggm\u00e4rg och spinalnerver. Genom denna forskning har\u00a0prof. Thomas Carlstedt och medarbetare utvecklat en operationsteknik (8) som visat att det g\u00e5r att s\u00e4tta tillbaks spinalnerver som slitits loss ur ryggm\u00e4rgen\u00a0vid olycksfall och \u00e5terf\u00e5 viss funktion. F\u00f6r n\u00e4rvarande \u00e4r operationstekniken ”vilande”. Vi beh\u00f6ver n\u00e5gon form av l\u00e4kemedelsadjuvans f\u00f6r att f\u00f6rb\u00e4ttra\u00a0resultaten.<\/p>\n

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V\u00e5r kurator Linda Geupel har i en\u00a0masteruppsats gjort en kvalitativ intervjustudie med ungdomar som har en f\u00f6delserelaterad plexus brachialisskada. Studien visar p\u00e5 deras upplevelser av sin skada, v\u00e5rden och hur de ser p\u00e5 sig sj\u00e4lva, utifr\u00e5n sin skada.<\/p>\n

Everyone is a variation of normal<\/a><\/p>\n

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Vi har i Stockholm tillsammans med Ume\u00e5 under 2021 p\u00e5b\u00f6rjat en enk\u00e4t- och intervjustudie f\u00f6r patienter med traumatisk plexusskada f\u00f6r att kunna se hur den rehabilitering dessa patienter f\u00e5r fungerar samt hur de m\u00e5r.<\/p>\n

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Nedan\u00a0f\u00f6ljer ett\u00a0urval av vetenskapliga publikationer som producerats av medarbetare i teamet. Vi har listat en liten del av det som publicerats, f\u00f6r att ge en bild av n\u00e5gra olika omr\u00e5den som vi forskar p\u00e5:<\/p>\n

Artiklar:<\/strong><\/p>\n

16. J\u00f6nsson K, Hultgren T, Risling M, Sk\u00f6ld MK:<\/em>\u00a0On the origins of co-contractions in Brachial plexus birth palsy. Changes in number and distribution of spinal cord motorneurons after injuries to cervical nerve roots in fetal rats.\u00a0 (\u00e4nnu ej publicerad 2022)<\/p>\n

15. K.J\u00f6nsson, F. Roos, T. Hultgren:<\/em>\u00a0Structures contributing to the shoulder contracture in brachial plexus birth palsy. AN intraoperative biomechanical study. J Hand Surg Eur vol. 2022 Mar;47 (3):237-242<\/p>\n

14. K.J\u00f6nsson, M. Werner; F. Roos, T. Hultgren:<\/em>\u00a0Development of the glenohumeral joint after supbscapular release and open relocation in children with brachial plexus birth palsy: long term results in 61 patients. J Shoulder Elbow surgery 2019 Oct;28(10) 1983-1990<\/p>\n

13. T. Hultgren, K. J\u00f6nsson, F. Roos, H. J\u00e4rnbert-Pettersson, H. Hammarberg:<\/em> Surgical correction of shoulder rotation deformity in brachialplexus birth palsy.\u00a0 Bone Joint J 2014;96-B1411-18<\/p>\n

12. Hultgren T, J\u00f6nsson K, Pettersson H, Hammarberg H:<\/em> Surgical correction of a rotational deformity of the shoulder in patients with obstetric brachial plexus palsy. Short term results in 270 patients. Bone Joint J 2013;95-B:1432\u20138<\/p>\n

11. Westin B, Hultgren T, von Koch L: Obstetric brachial plexus injury: expectations before and satisfaction three months after secondary surgery on the shoulder. Hand Therapy 2012; 17: 95\u201399<\/p>\n

10. Sk\u00f6ld M, Svensson M, Tsao J, Hultgren T, Landegren T, Carlstedt T, Cullheim S (2011). Karolinska Institutet 200 year anniversary.-Symposium on traumatic injuries in the nervous system. Injuries to the spinal cord and peripheral nervous system-Injuries and repair, pain problems, lesions to brachial plexus. Frontiers in Neurotrauma. 2,29,1-5<\/p>\n

9. Hultgren T, Einarsson F, Runesson E, Hemlin C, Frid\u00e9n J, Ljung BO: Structural characteristics of the subscapularis muscle in children with medial rotation contracture of the shoulder after obstetric brachial plexus injury. J Hand Surg (Eur) 2010; 35E: 1: 23\u201328<\/p>\n

8. Carlstedt T, Hultgren T, Nyman T, Hansson T. Cortical activity and hand function restoration in a patient after spinal cord surgery. Nature Rev. Neurol. 5, 571\u2013574 (2009)<\/p>\n

7. Remahl S, Angeria M,Nilsson Remahl I, Carlstedt T, Risling M. Observation at the PNS-CNS border of ventral roots connected to a neuroma. Frontiers in Neurotrauma 1,article 136,1-6 .(2010)<\/p>\n

6. Shi TJ, Liu SX, Hammarberg H, Watanabe M, Xu ZQ, H\u00f6kfelt T. Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain: Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20004-8<\/p>\n

5. Str\u00f6mbeck C, Remahl S, Krumlinde-Sundholm L, Sejersen T (2007) Long term functional follow up of children with obstetrical brachial plexus palsy II: neurophysiological aspects. Dev Med Child Neurol 49(3):204-9.<\/p>\n

4. Krumlinde-Sundholm L, Holmefur M, Kottorp A, Eliasson AC (2007) The Assisting Hand Assessment: Current evidence of validity, reliability and responsiveness to change. Dev Med Child Neurol 49(4):259-64.<\/p>\n

3.Krumlinde-Sundholm L., Eliasson A. (2003) Development of the Assisting Hand Assessment, a Rasch built measure intended for children with unilateral upper limb impairments. Scand J Occup Ther. 10: 16-26<\/p>\n

2.Str\u00f6mbeck C, Krumlinde-Sundholm L, Forssberg H: Functional outcome at 5 years in children with obstetrical brachial plexus palsy with and without microsurgical reconstruction. Dev Med Child Neurol. (2000) 42(3):148-57<\/p>\n

1. Krumlinde Sundholm L, Eliasson A, Forssberg H (1998) Obstetric brachial plexus injuries: assessment protocol and functional outcome at age 5 years, Dev Med Child Neurol. 40(1): 4-11<\/p>\n

Avhandlingar:<\/strong><\/p>\n

K. J\u00f6nsson: 2022 Rotation and Development of the Glenohumeral Joint in Brachial Plexus Birth Palsy<\/p>\n

T. Hultgren 2013: On the rotational deformity of the shoulder following an obstetric brachial plexus injury.<\/p>\n

T. Landegren 2010: Central and periferal adaptaion after nerve repair with a synthetic biocompatible adhesive.<\/p>\n

C. Str\u00f6mbeck 2006: Follow-up studies of the obstetrical brachial plexus injury.<\/p>\n

L. Krumlinde Sundholm 2002: Aspects of hand function in children with unilateral impairments.<\/p>\n

Bok:<\/strong><\/p>\n

T. Carlstedt (2007). Central Nerve Plexus Injury. Imperial College Press<\/p>\n

Bokkapitel<\/strong><\/p>\n

T.Carlstedt.(2009) Nerve Root Replantation. In Neurosurgical Clinics of North America. Ed. Spinner Winfree C.J. 20:39-50.<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Plexusgruppens forskningsprojekt ber\u00f6r flera olika omr\u00e5den. Flera\u00a0forskningsprojekt\u00a0bedrivs\u00a0inom ramen f\u00f6r det kliniska arbetet\u00a0\u00a0och handlar bland annat om att utveckla instrument f\u00f6r att utv\u00e4rdera funktionen hos personer som drabbats av plexusskador och att utv\u00e4rdera effekten av kirurgisk behandling av olika slag, b\u00e5de betr\u00e4ffande reparation av nervskador och vad g\u00e4ller det vi kallar sekund\u00e4r kirurgi. Barn med en […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/211"}],"collection":[{"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=211"}],"version-history":[{"count":28,"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/211\/revisions"}],"predecessor-version":[{"id":861,"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/211\/revisions\/861"}],"wp:attachment":[{"href":"https:\/\/plexusskada.se\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=211"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}